Spatial patterns of alpha-synuclein positive glial cytoplasmic inclusions in multiple system atrophy

Mov Disord. 2004 Jan;19(1):109-12. doi: 10.1002/mds.10637.

Abstract

In cases of multiple system atrophy (MSA), glial cytoplasmic inclusions (GCI) were distributed randomly or present in large diffuse clusters (>1,600 microm in diameter) in most areas studied. These spatial patterns contrast with those reported for filamentous neuronal inclusions in the tauopathies and alpha-synucleinopathies.

MeSH terms

  • Aged
  • Aged, 80 and over
  • Brain / pathology
  • Diagnosis, Differential
  • Female
  • Humans
  • Inclusion Bodies / pathology*
  • Male
  • Middle Aged
  • Multiple System Atrophy / pathology*
  • Nerve Net / pathology
  • Nerve Tissue Proteins / analysis*
  • Neurofibrils / pathology
  • Neuroglia / pathology*
  • Neurons / pathology
  • Olivopontocerebellar Atrophies / pathology
  • Shy-Drager Syndrome / pathology
  • Striatonigral Degeneration / pathology
  • Synucleins
  • alpha-Synuclein

Substances

  • Nerve Tissue Proteins
  • SNCA protein, human
  • Synucleins
  • alpha-Synuclein