Abstract
To clarify the role of chymase in adhesion formation, we investigated whether a chymase inhibitor could prevent adhesion formation after surgery in hamsters. Hamsters received a lesion produced by uterus scraping. A specific chymase inhibitor, 2-[4-(5-fluoro-3-methylbenzo[b]thiophen-2-yl)sulfonamido-3-methanesulfonylphenyl]oxazole-4-carboxylicacid (TY-51184), or placebo was injected into the abdomen before closing and scores for adhesion formation were assessed at 1, 4, and 12 weeks. A single peritoneal administration of TY-51184 significantly decreased the adhesion scores even at 12 weeks (placebo, 2.80+/-0.20; chymase inhibitor, 1.60+/-0.31). Thus, chymase inhibitors may be a novel strategy to prevent adhesion formation.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Chymases
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Cricetinae
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Female
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Mesocricetus
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Oxazoles / pharmacology
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Oxazoles / therapeutic use
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Peritoneal Cavity / pathology
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Peritoneal Cavity / surgery
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Serine Endopeptidases / metabolism*
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Serine Proteinase Inhibitors / pharmacology
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Serine Proteinase Inhibitors / therapeutic use*
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Sulfonamides / pharmacology
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Sulfonamides / therapeutic use
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Tissue Adhesions / enzymology*
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Tissue Adhesions / prevention & control*
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Uterus / drug effects
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Uterus / enzymology
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Uterus / pathology
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Uterus / surgery
Substances
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2-(4-(5-fluoro-3-methylbenzo(b)thiophen-2-yl)sulfonamide-3-methanesulfonylphenyl)oxazole-4-carboxylic acid
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Oxazoles
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Serine Proteinase Inhibitors
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Sulfonamides
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Serine Endopeptidases
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Chymases