Reversible language regression as an adverse effect of topiramate treatment in children

Neurology. 2004 Jan 27;62(2):299-300. doi: 10.1212/01.wnl.0000103285.85821.b3.

Abstract

Profound language regression developed in three children with epilepsy 4 to 28 weeks after beginning topiramate (TPM). TPM was administered as an adjunctive antiepileptic drug at doses of 2.5 to 6.0 mg/kg/day. Language functions recovered while TPM was being reduced in dose or stopped.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Anticonvulsants / adverse effects*
  • Anticonvulsants / therapeutic use
  • Child
  • Child, Preschool
  • Epilepsy, Complex Partial / complications
  • Epilepsy, Complex Partial / drug therapy
  • Epilepsy, Generalized / complications
  • Epilepsy, Generalized / drug therapy
  • Epilepsy, Tonic-Clonic / complications
  • Epilepsy, Tonic-Clonic / drug therapy
  • Female
  • Fructose / adverse effects*
  • Fructose / analogs & derivatives*
  • Fructose / therapeutic use
  • Humans
  • Language Disorders / chemically induced*
  • Speech Disorders / chemically induced*
  • Topiramate

Substances

  • Anticonvulsants
  • Topiramate
  • Fructose