Identification of heat stable protease of Klebsiella oxytoca isolated from raw milk

Lett Appl Microbiol. 2004;38(2):146-50. doi: 10.1111/j.1472-765x.2003.01461.x.

Abstract

Aims: The aim of this study was to identify and characterize heat stable proteinases of psychrotrophic proteolytic bacteria isolated from raw milk.

Methods and results: A strain of Klebsiella oxytoca producing a high proteolytic activity when cultured on milk was isolated. Maximum proteolytic activity was observed at the stationary phase during growth on milk or casein-peptone broth. The bacterium demonstrated the capability to grow at 7 degrees C, classified as psychrotrophic. The crude enzyme showed optimum activity at 37 degrees C, and pH 5.0 and 7.0. The proteinase was very resistant to heat, maintaining 74% of initial activity after incubation at 142 degrees C.

Conclusions: A heat stable protease of a psychrotrophic strain of K. oxytoca was identified and partially characterized.

Significance and impact of the study: Thermal stable proteases may constitute a serious problem to ultra-high temperature (UHT) processed milk, leading to undesirable physical and sensory alterations.

MeSH terms

  • Animals
  • Enzyme Stability
  • Food Microbiology
  • Hydrogen-Ion Concentration
  • Klebsiella oxytoca / enzymology*
  • Klebsiella oxytoca / growth & development
  • Klebsiella oxytoca / isolation & purification*
  • Milk / microbiology*
  • Peptide Hydrolases / metabolism*
  • Temperature

Substances

  • Peptide Hydrolases