The author describes hyperemesis gravidarum clinical, biochemical and hormonal chart. He also refers the features of HCG molecule, its connections with hormones, which there are also glycoprotein and its plasmatic changes in normal pregnancy. The association between hyperemesis gravidarum and hyperthyroidism is extremely important in the patient's clinical evaluation. He also alludes to the special hyperthyroidism features concerning hyperemesis gravidarum, as well as when and how to treat it.