Determination of thiopurine methyltransferase activity in isolated human erythrocytes does not reflect putative in vivo enzyme inhibition by sulfasalazine

Clin Chem. 2004 Feb;50(2):438-41. doi: 10.1373/clinchem.2003.026096.

Authors

Maria Shipkova¹, Paul Dieter Niedmann, Victor W Armstrong, Michael Oellerich, Eberhard Wieland

Affiliation

¹ Central Institute for Clinical Chemistry and Laboratory Medicine, Klinikum Stuttgart, Germany. [email protected]

PMID: 14752016
DOI: 10.1373/clinchem.2003.026096

No abstract available

MeSH terms

Erythrocytes / enzymology*
Humans
In Vitro Techniques
Methyltransferases / antagonists & inhibitors*
Methyltransferases / blood*
Methyltransferases / deficiency
Sulfasalazine / adverse effects*
Sulfasalazine / therapeutic use

Substances

Sulfasalazine
Methyltransferases
thiopurine methyltransferase