Abstract
Preclinical research suggests adrenal beta-adrenergic receptors to be involved in the regulation of steroid synthesis. In a group of healthy male volunteers, we compared ACTH-induced cortisol and dehydroepiandrosterone (DHEA) secretion after pre-treatment with orciprenaline, propranolol or placebo. Neither baseline nor ACTH-induced steroid secretion differed between these conditions. Our data do not support the hypothesis that the adrenal beta-receptor plays a major role in steroid secretion in humans.
Publication types
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Clinical Trial
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Randomized Controlled Trial
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Research Support, Non-U.S. Gov't
MeSH terms
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Adrenergic beta-Agonists / pharmacology*
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Adrenergic beta-Antagonists / pharmacology*
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Adrenocorticotropic Hormone / metabolism
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Adrenocorticotropic Hormone / physiology*
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Adult
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Cosyntropin / metabolism
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Dehydroepiandrosterone / blood
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Dehydroepiandrosterone / metabolism
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Humans
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Hydrocortisone / blood
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Hydrocortisone / metabolism*
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Male
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Metaproterenol / pharmacology*
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Pituitary-Adrenal System / metabolism
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Propranolol / pharmacology*
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Receptors, Adrenergic, beta / metabolism*
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Secretory Rate / drug effects
Substances
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Adrenergic beta-Agonists
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Adrenergic beta-Antagonists
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Receptors, Adrenergic, beta
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Cosyntropin
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Dehydroepiandrosterone
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Metaproterenol
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Adrenocorticotropic Hormone
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Propranolol
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Hydrocortisone