Abstract
The receptor for IL-26 (AK155), a cytokine of the IL-10 family, has not previously been defined. We demonstrate that the active receptor complex for IL-26 is a heterodimer composed of two receptor proteins: IL-20R1 and IL-10R2. Signaling through the IL-26R results in activation of STAT1 and STAT3 which can be blocked by neutralizing Abs against IL-20R1 or IL-10R2. IL-10R2 is broadly expressed on a wide variety of tissues, whereas only a limited number of tissues express IL-20R1. Therefore, the ability to respond to IL-26 is restricted by the expression of IL-20R1. IL-10, IL-19, IL-20, IL-22, and IL-24 fail to signal through the combination of IL-10R2 and IL-20R1 proteins, demonstrating that this receptor combination is unique and specific for IL-26.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Cell Line
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Cell Line, Tumor
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DNA-Binding Proteins / metabolism
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Dimerization
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HT29 Cells
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Humans
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Interleukin-10 / metabolism*
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Interleukins / metabolism*
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Interleukins / physiology*
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Organ Specificity / genetics
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Organ Specificity / immunology
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Protein Isoforms / biosynthesis
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Protein Isoforms / genetics
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Protein Isoforms / physiology
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Receptors, Interleukin / biosynthesis
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Receptors, Interleukin / genetics
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Receptors, Interleukin / physiology*
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Receptors, Interleukin-10
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STAT1 Transcription Factor
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STAT3 Transcription Factor
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Signal Transduction / immunology*
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Trans-Activators / metabolism
Substances
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DNA-Binding Proteins
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IL26 protein, human
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Interleukins
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Protein Isoforms
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Receptors, Interleukin
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Receptors, Interleukin-10
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STAT1 Transcription Factor
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STAT1 protein, human
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STAT3 Transcription Factor
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STAT3 protein, human
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Trans-Activators
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Interleukin-10
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interleukin 20