Microwave-assisted synthesis of allylic amines: considerable rate acceleration in the hydrozirconation-transmetalation-aldimine addition sequence

Org Biomol Chem. 2004 Feb 21;2(4):443-5. doi: 10.1039/b316741k. Epub 2004 Jan 28.

Abstract

The hydrozirconation of alkynes with zirconocene hydrochloride and the dimethylzinc-mediated addition of alkenylzirconocenes to diphenylphosphinoyl imines can be greatly accelerated with microwave irradiation, resulting in a convenient and rapid one-pot process for the preparation of synthetically useful allylic amines.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Allyl Compounds / chemical synthesis*
  • Amines / chemical synthesis*
  • Hydrogen / chemistry*
  • Imines / chemistry*
  • Microwaves
  • Molecular Structure
  • Silicates / chemistry*
  • Zirconium / chemistry*

Substances

  • Allyl Compounds
  • Amines
  • Imines
  • Silicates
  • zircon
  • Hydrogen
  • Zirconium