Abstract
The semaphorin proteins were identified originally as axonal guidance factors functioning during neuronal development. In addition to this function, several semaphorins play diverse roles outside the nervous system. The class 4 semaphorin CD100/Sema4D, which utilizes plexin-B1 and CD72 as receptors, exerts important biological effects on a variety of cells, including the neuronal, epithelial and immune cells. Here, we review recent advances exploring the molecular mechanisms governing the biological functions of CD100/Sema4D.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Antigens, CD / metabolism
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Antigens, Differentiation, B-Lymphocyte / metabolism
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Cell Line
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GTP Phosphohydrolases / metabolism
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Humans
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Ligands
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Membrane Glycoproteins / chemistry
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Membrane Glycoproteins / genetics
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Membrane Glycoproteins / metabolism*
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Nerve Tissue Proteins*
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Proprotein Convertases / metabolism
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Receptors, Cell Surface*
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Semaphorins*
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Signal Transduction / physiology*
Substances
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Antigens, CD
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Antigens, Differentiation, B-Lymphocyte
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CD100 antigen
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CD72 protein, human
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Ligands
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Membrane Glycoproteins
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Nerve Tissue Proteins
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PLXNB1 protein, human
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Receptors, Cell Surface
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Semaphorins
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Proprotein Convertases
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GTP Phosphohydrolases