Abstract
Four patients treated with fluoxetine alone developed generalized urticaria. One also suffered polyarthritis. These reactions subsided when fluoxetine was stopped. After 6-12 months, because of progressive psychiatric problems, fluoxetine was reintroduced using a desensitization protocol. In each case this was well tolerated, and fluoxetine has been continued without adverse affects for 3-10 months.
MeSH terms
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Adult
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Clinical Protocols
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Depressive Disorder / drug therapy
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Desensitization, Immunologic / methods*
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Dose-Response Relationship, Drug
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Drug Administration Schedule
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Drug Eruptions / etiology
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Drug Eruptions / prevention & control*
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Female
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Fluoxetine / adverse effects*
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Fluoxetine / immunology
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Fluoxetine / therapeutic use
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Humans
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Male
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Middle Aged
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Obsessive-Compulsive Disorder / drug therapy
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Urticaria / chemically induced
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Urticaria / prevention & control