Physico-chemical modeling of the role of free radicals in photo-dynamic therapy. I. Utilization of quantum yield data of singlet oxygen formation for the study of the interaction between excited photosensitizer and stable free radicals

Biochem Biophys Res Commun. 1992 Dec 30;189(3):1548-52. doi: 10.1016/0006-291x(92)90252-g.

Abstract

The measurement of the relative quantum yield of singlet oxygen formation, a simple process without tedious sample deoxygenation, is shown to furnish data on the interaction of the excited photosensitizer with any additive (in this case stable free radicals) given to the sample. The rate constants derived from such measurements are in good agreement with direct determination of the corresponding values.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Free Radicals
  • Hematoporphyrins / chemistry*
  • Kinetics
  • Oxygen*
  • Photochemistry
  • Photochemotherapy*
  • Quantum Theory
  • Radiation-Sensitizing Agents / chemistry*
  • Singlet Oxygen

Substances

  • Free Radicals
  • Hematoporphyrins
  • Radiation-Sensitizing Agents
  • Singlet Oxygen
  • Oxygen