Abstract
Several isopropyl and phenyl esters of 3 beta-(4-substituted phenyl) tropan-2 beta-carboxylic acid analogs of cocaine are relatively more potent and selective than cocaine and some other compounds in inhibiting dopamine uptake. These analogs can be used as binding ligands and as tools for elucidating the mechanisms of action of cocaine.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Carrier Proteins / metabolism*
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Cocaine / analogs & derivatives*
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Cocaine / pharmacology*
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Dopamine / metabolism
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Dopamine Plasma Membrane Transport Proteins
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Ligands
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Male
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Membrane Glycoproteins*
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Membrane Transport Proteins*
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Nerve Tissue Proteins*
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Norepinephrine / metabolism
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Rats
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Rats, Sprague-Dawley
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Serotonin / metabolism
Substances
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Carrier Proteins
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Dopamine Plasma Membrane Transport Proteins
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Ligands
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Membrane Glycoproteins
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Membrane Transport Proteins
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Nerve Tissue Proteins
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Serotonin
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Cocaine
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Dopamine
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Norepinephrine