3-Methyl pyrrole-2,4-dicarboxylic acid 2-propyl ester 4-(1,2,2-trimethyl-propyl) ester: an exploration of the C-2 position. Part II, A solid-phase approach

Fabrizio Micheli; Romano Di Fabio; Palmina Cavallini; Paolo Cavanni; Daniele Donati; Mahmoud Hamdan; Fabio Maria Sabbatini; Tommaso Messeri

doi:10.1016/j.farmac.2003.12.006

3-Methyl pyrrole-2,4-dicarboxylic acid 2-propyl ester 4-(1,2,2-trimethyl-propyl) ester: an exploration of the C-2 position. Part II, A solid-phase approach

Farmaco. 2004 Feb;59(2):119-23. doi: 10.1016/j.farmac.2003.12.006.

Authors

Fabrizio Micheli¹, Romano Di Fabio, Palmina Cavallini, Paolo Cavanni, Daniele Donati, Mahmoud Hamdan, Fabio Maria Sabbatini, Tommaso Messeri

Affiliation

¹ GlaxoSmithKline Medicine Research Centre, via Fleming 4, Verona 37135, Italy. [email protected]

PMID: 14871503
DOI: 10.1016/j.farmac.2003.12.006

Abstract

Following the recent disclosure (Part I of this paper) of 3-methyl pyrrole-2,4-dicarboxylic acid 2-propyl ester 4-(1,2,2-trimethyl-propyl) amides and of their improved pharmacokinetic profile with respect to the originally reported esters, a further exploration of the C-2 position through a solid-phase approach is reported here.

MeSH terms

Chemical Phenomena
Chemistry, Physical
Chromatography, High Pressure Liquid
Esters / chemical synthesis*
Esters / pharmacology*
Excitatory Amino Acid Antagonists / chemical synthesis*
Excitatory Amino Acid Antagonists / pharmacology*
Magnetic Resonance Spectroscopy
Mass Spectrometry
Pyrroles / chemical synthesis*
Pyrroles / pharmacology*
Spectrophotometry, Infrared
Structure-Activity Relationship

Substances

3-methyl pyrrole-2,4-dicarboxylic acid 2-propyl ester 4-(1,2,2-trimethyl-propyl) ester
Esters
Excitatory Amino Acid Antagonists
Pyrroles