The genes coding for phosphoenolpyruvate carboxykinase-1 (PCK1) and neuronal nicotinic acetylcholine receptor alpha 4 subunit (CHRNA4) map to human chromosome 20, extending the known region of homology with mouse chromosome 2

Ann Hum Genet. 1992 Oct;56(4):289-93. doi: 10.1111/j.1469-1809.1992.tb01155.x.

Abstract

The mouse genes for cytosolic phosphoenolpyruvate carboxykinase-1 (Pck-1) and neuronal nicotinic acetylcholine receptor alpha 4 subunit (Acra-4) both map to distal chromosome 2 (Siracusa et al. 1989; Bessis et al. 1990). We have utilized Southern blot analysis on human/rodent somatic cell hybrids to map the human homologues of both of these genes, PCK1 and CHRNA4, to human chromosome 20.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Blotting, Southern
  • Chromosome Mapping
  • Chromosomes, Human, Pair 20*
  • Cricetinae
  • Humans
  • Hybrid Cells / ultrastructure
  • Mice / genetics
  • Phosphoenolpyruvate Carboxykinase (GTP) / genetics*
  • Rats
  • Receptors, Nicotinic / genetics*
  • Species Specificity

Substances

  • Receptors, Nicotinic
  • Phosphoenolpyruvate Carboxykinase (GTP)