Abstract
A series of fluorenone and benzophenone 1,4-dihydropyridine derivatives were prepared. The compounds were evaluated for inotropic, chronotropic and calcium antagonist properties.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anti-Arrhythmia Agents / chemical synthesis*
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Anti-Arrhythmia Agents / pharmacology
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Benzophenones / chemical synthesis*
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Benzophenones / pharmacology
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Calcium Channel Blockers / chemical synthesis
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Calcium Channel Blockers / pharmacology
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Chemical Phenomena
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Chemistry, Physical
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Dihydropyridines / chemical synthesis*
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Dihydropyridines / pharmacology
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Female
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Fluorenes / chemical synthesis*
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Fluorenes / pharmacology
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Guinea Pigs
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Heart Rate / drug effects
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In Vitro Techniques
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Male
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Muscle Contraction / drug effects
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Muscle, Smooth, Vascular / drug effects
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Myocardial Contraction / drug effects
Substances
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Anti-Arrhythmia Agents
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Benzophenones
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Calcium Channel Blockers
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Dihydropyridines
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Fluorenes