Electroconvulsive therapy (ECT) is a highly effective treatment for patients with severe major depressive disorder. ECT can safely be administered even to medically ill, high-risk patients; we report on the complete remission of depressive psychopathology following five unilateral ECT treatments in a suicidal geriatric patient with concurrent prior venous thrombosis, coronary heart disease, multiple myeloma, glaucoma, bilateral petrous bone fractures, and a femoral neck fracture. Most medical complications during ECT can be managed with interdisciplinary cooperation.