Abstract
The kinetics of the effect of fusidic acid and of two fluoropiperazinyl quinolones (ofloxacin and pefloxacin), used alone or in combination, on ten methicillin-susceptible or methicillin-resistant strains of staphylococci were studied. Little or no bactericidal effects were seen with fusidic acid. With ofloxacin and pefloxacin, the bactericidal effect was delayed and occurred only with high concentrations. Used in combination, fusidic acid and the fluoroquinolones exhibited no synergistic effects and occasionally antagonized each other in vitro. The methicillin-resistance phenotype of organisms had no influence on results.
MeSH terms
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Bone Diseases / drug therapy
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Bone Diseases / microbiology
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Dose-Response Relationship, Drug
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Drug Therapy, Combination / pharmacokinetics
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Drug Therapy, Combination / pharmacology
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Drug Therapy, Combination / therapeutic use
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Fusidic Acid / pharmacokinetics
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Fusidic Acid / pharmacology*
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Fusidic Acid / therapeutic use
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Humans
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In Vitro Techniques
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Joint Diseases / drug therapy
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Joint Diseases / microbiology
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Methicillin / pharmacology
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Methicillin Resistance
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Ofloxacin / pharmacokinetics
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Ofloxacin / pharmacology*
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Ofloxacin / therapeutic use
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Pefloxacin / pharmacokinetics
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Pefloxacin / pharmacology*
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Pefloxacin / therapeutic use
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Staphylococcal Infections / drug therapy
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Staphylococcal Infections / microbiology
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Staphylococcus aureus / drug effects*
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Staphylococcus aureus / isolation & purification
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Staphylococcus epidermidis / drug effects*
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Staphylococcus epidermidis / isolation & purification
Substances
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Pefloxacin
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Fusidic Acid
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Ofloxacin
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Methicillin