Abstract
DC-SIGN, a specific C-type lectin expressed on dendritic cells, binds and transmits multiple strains of primate immunodeficiency viruses to susceptible cells. Here, we report that human DC-SIGN also captures feline immunodeficiency virus via high-affinity (1 nM), Ca(2+)-dependent, D-mannose-inhibited binding to the major envelope glycoprotein, gp95.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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CHO Cells
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Cats
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Cell Adhesion Molecules / antagonists & inhibitors
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Cell Adhesion Molecules / genetics
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Cell Adhesion Molecules / metabolism*
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Cell Line
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Cricetinae
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HIV-1 / metabolism
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Humans
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Immunodeficiency Virus, Feline / metabolism*
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Immunodeficiency Virus, Feline / physiology
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Intercellular Adhesion Molecule-1 / metabolism
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Lectins, C-Type / antagonists & inhibitors
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Lectins, C-Type / genetics
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Lectins, C-Type / metabolism*
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Mannose / pharmacology
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Membrane Glycoproteins / antagonists & inhibitors
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Membrane Glycoproteins / metabolism*
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Organ Specificity
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Protein Binding / drug effects
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Receptors, Cell Surface / antagonists & inhibitors
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Receptors, Cell Surface / genetics
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Receptors, Cell Surface / metabolism*
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T-Lymphocytes / metabolism
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T-Lymphocytes / virology
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Viral Envelope Proteins / antagonists & inhibitors
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Viral Envelope Proteins / metabolism*
Substances
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Cell Adhesion Molecules
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DC-specific ICAM-3 grabbing nonintegrin
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Lectins, C-Type
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Membrane Glycoproteins
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Receptors, Cell Surface
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Viral Envelope Proteins
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Intercellular Adhesion Molecule-1
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Mannose