A protein interaction domain contacts RNA in the prespliceosome

Mol Cell. 2004 Feb 13;13(3):302-4. doi: 10.1016/s1097-2765(04)00055-3.

Abstract

SR proteins bind to exons and recruit the spliceosome via protein interactions mediated by an arginine-serine-rich (RS) domain. In this issue of Molecular Cell, demonstrate that the RS domain of SR proteins contacts the pre-mRNA branchpoint, indicating that these domains participate in both protein and RNA interactions.

Publication types

  • Comment
  • Review

MeSH terms

  • Animals
  • Enhancer Elements, Genetic / genetics
  • Humans
  • Models, Molecular
  • Protein Structure, Tertiary / genetics
  • RNA / metabolism*
  • RNA Splicing / genetics*
  • RNA-Binding Proteins / genetics*
  • Ribonucleoproteins, Small Nuclear / genetics
  • Serine / genetics
  • Spliceosomes / genetics*

Substances

  • RNA-Binding Proteins
  • Ribonucleoproteins, Small Nuclear
  • Serine
  • RNA