A case of spleen abscess complicating Salmonella bacteremia in a HIV-infected patient is reported for the first time. Chronic pancreatitis and the infection of a pre-existing pseudocyst of the pancreas tail might have been the predisposing factor. Infection developed before other AIDS criteria were evident in the patient. Splenectomy plus antibiotic therapy was required to eradicate the process. Salmonella enteritidis was cultured from two suppurated lesions of the excised organ.