Tumor necrosis factor alpha gene-G308A polymorphism associated with bipolar I disorder in the Korean population

C-U Pae; K-U Lee; H Han; A Serretti; T-Y Jun

doi:10.1016/j.psychres.2003.06.002

Tumor necrosis factor alpha gene-G308A polymorphism associated with bipolar I disorder in the Korean population

Psychiatry Res. 2004 Jan 30;125(1):65-8. doi: 10.1016/j.psychres.2003.06.002.

Authors

C-U Pae¹, K-U Lee, H Han, A Serretti, T-Y Jun

Affiliation

¹ Department of Psychiatry, Kangnam St. Mary's Hospital, Catholic University of Korea College of Medicine, Seoul, South Korea.

PMID: 14967554
DOI: 10.1016/j.psychres.2003.06.002

Abstract

We conducted a case-control association study between the -G308A tumor necrosis factor (TNF)-alpha gene polymorphism and 89 patients with bipolar I disorder (BID). A polymerase chain reaction method was used. We found significant differences in genotype and allele distribution. The -G308A TNF-alpha gene polymorphism may confer a risk for BID in the Korean population.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Bipolar Disorder / ethnology*
Bipolar Disorder / genetics*
Female
Gene Expression / genetics*
Gene Frequency
Humans
Korea
Male
Polymorphism, Genetic / genetics*
Population Surveillance / methods
Tumor Necrosis Factor-alpha / genetics*

Substances

Tumor Necrosis Factor-alpha