Pregnant drug abusers are a group with very high risk of perinatal morbidity. Intensive prenatal care, with substitution maintenance programs, by a medico-psycho-social team working in concert with ambulatory health and social workers, may prevent perinatal complications and mother-infant separation. The results of such a perinatal program, in a suburban low-socioeconomic population, are described. In comparison with reports in the literature, this approach appears to provide significant perinatal medical and social prognosis for pregnant abusers and their neonates.