ALL-1/MLL1, a homologue of Drosophila TRITHORAX, modifies chromatin and is directly involved in infant acute leukaemia

Br J Cancer. 2004 Feb 23;90(4):756-60. doi: 10.1038/sj.bjc.6601639.

Abstract

Rearrangements of the ALL-1/MLL1 gene underlie the majority of infant acute leukaemias, as well as of therapy-related leukaemias developing in cancer patients treated with inhibitors of topoisomerase II, such as VP16 and doxorubicin. The rearrangements fuse ALL-1 to any of >50 partner genes or to itself. Here, we describe the unique features of ALL-1-associated leukaemias, and recent progress in understanding molecular mechanisms involved in the activity of the ALL-1 protein and of its Drosophila homologue TRITHORAX.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Cell Transformation, Neoplastic
  • Chromatin / metabolism*
  • DNA-Binding Proteins / pharmacology*
  • Disease Models, Animal
  • Drosophila / genetics
  • Drosophila Proteins / pharmacology*
  • Gene Expression Regulation, Neoplastic*
  • Histone-Lysine N-Methyltransferase / pharmacology*
  • Humans
  • Leukemia, Myeloid, Acute / genetics*
  • Leukemia, Myeloid, Acute / physiopathology
  • Mice
  • Myeloid-Lymphoid Leukemia Protein
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics*
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / physiopathology
  • Proto-Oncogenes*
  • Transcription Factors*
  • Zinc Fingers

Substances

  • Chromatin
  • DNA-Binding Proteins
  • Drosophila Proteins
  • KMT2A protein, human
  • Transcription Factors
  • Myeloid-Lymphoid Leukemia Protein
  • Histone-Lysine N-Methyltransferase
  • Kmt2a protein, mouse
  • TRR protein, Drosophila