A direct meta-lithiation route to 1,3-disubstituted ferrocenes

Chem Commun (Camb). 2004 Mar 7:(5):598-9. doi: 10.1039/b314641c. Epub 2004 Feb 10.

Abstract

Ferrocenyl sulfides afford meta-lithiation products with up to 94% regioselectivity on reaction with s-BuLi; the resulting 1,3-disubstituted ferrocenes can then be reacted with a variety of electrophiles.