Abstract
The clinical picture of neurological involvement in Whipple's disease (WD) may resemble progressive supranuclear palsy (PSP). We looked for WD pathogen DNA in the cerebrospinal fluid of 9 patients with a clinical diagnosis of PSP. The analysis was negative for all samples, showing that WD is not commonly involved in the aetiopathogenesis of PSP.
MeSH terms
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Aged
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Brain / pathology
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Cerebrospinal Fluid Proteins / cerebrospinal fluid*
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DNA, Bacterial / cerebrospinal fluid*
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Diagnosis, Differential
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Female
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Gram-Positive Bacteria / genetics*
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Gram-Positive Bacterial Infections / cerebrospinal fluid
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Gram-Positive Bacterial Infections / diagnosis*
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Humans
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Magnetic Resonance Imaging
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Male
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Middle Aged
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Neurologic Examination
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Polymerase Chain Reaction
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Supranuclear Palsy, Progressive / cerebrospinal fluid
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Supranuclear Palsy, Progressive / diagnosis*
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Whipple Disease / cerebrospinal fluid
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Whipple Disease / diagnosis*
Substances
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Cerebrospinal Fluid Proteins
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DNA, Bacterial