Abstract
2-(6-aryl-3-hexen-1,5-diynyl)benzonitriles 3a-j showed growth inhibition effects on a full panel of 60 human cancer cell lines in low micro-concentrations, in which compounds 3c,d displayed a significant G2/M arrest in the cell growth cycle compared with other derivatives and an apoptotic progress induction were also shown by 3a-d.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Antineoplastic Agents / chemical synthesis*
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Antineoplastic Agents / pharmacology
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Apoptosis / drug effects*
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Cell Line, Tumor
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G2 Phase / drug effects
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Humans
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Interphase / drug effects*
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Mitosis / drug effects
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Nitriles / chemical synthesis*
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Nitriles / pharmacology*
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Structure-Activity Relationship
Substances
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Antineoplastic Agents
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Nitriles
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benzonitrile