Synthesis of 5'-C-methyl-1',3'-dioxolan-4'-yl nucleosides

Bioorg Med Chem Lett. 2004 Mar 8;14(5):1243-5. doi: 10.1016/j.bmcl.2003.12.060.

Abstract

Novel racemic 5'-C-methyl-1',3'-dioxolan-4'-yl nucleosides were synthesized from the key intermediate, 2-benzoyloxymethyl-4-oxo-5-C-methyl-1,3-dioxolane, which was prepared from racemic lactic acid.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Dioxolanes / chemical synthesis*
  • Nucleosides / chemical synthesis*

Substances

  • Dioxolanes
  • Nucleosides