Ribosomal mutations in Arcanobacterium pyogenes confer a unique spectrum of macrolide resistance

B Helen Jost; Hien T Trinh; J Glenn Songer; Stephen J Billington

doi:10.1128/AAC.48.3.1021-1023.2004

Ribosomal mutations in Arcanobacterium pyogenes confer a unique spectrum of macrolide resistance

Antimicrob Agents Chemother. 2004 Mar;48(3):1021-3. doi: 10.1128/AAC.48.3.1021-1023.2004.

Authors

B Helen Jost¹, Hien T Trinh, J Glenn Songer, Stephen J Billington

Affiliation

¹ Department of Veterinary Science and Microbiology, The University of Arizona, Tucson, Arizona 85721, USA. [email protected]

Abstract

Four macrolide-resistant Arcanobacterium pyogenes isolates contained A2058T, A2058G, or C2611G (Escherichia coli numbering) mutations in their 23S rRNA genes. While these mutations conferred resistance to erythromycin, oleandomycin, and spiramycin, they did not confer resistance to tylosin.

MeSH terms

Actinomycetaceae / drug effects*
Actinomycetaceae / genetics*
Anti-Bacterial Agents / pharmacology*
Drug Resistance, Bacterial / genetics
Macrolides / pharmacology*
Microbial Sensitivity Tests
Molecular Sequence Data
Mutation / physiology*
RNA, Ribosomal, 23S / genetics
Ribosomes / drug effects
Ribosomes / genetics*

Substances

Anti-Bacterial Agents
Macrolides
RNA, Ribosomal, 23S

Associated data

GENBANK/AY375319
GENBANK/AY375320
GENBANK/AY375321
GENBANK/AY375322
GENBANK/AY375323
GENBANK/AY375324
GENBANK/AY375325