Abstract
For the treatment of rabbit endocarditis, dalbavancin given once daily (10 mg/kg of body weight for 4 days) or as a single 40-mg/kg dose was active against Staphylococcus aureus with or without reduced susceptibility to glycopeptides, as expected from its good in vitro activity, even in broth supplemented with 90% serum and given its prolonged elimination half-life.
MeSH terms
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Animals
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Area Under Curve
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Colony Count, Microbial
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Drug Resistance, Bacterial
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Endocarditis, Bacterial / drug therapy*
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Endocarditis, Bacterial / microbiology
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Female
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Glycopeptides / therapeutic use*
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Half-Life
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Rabbits
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Staphylococcal Infections / drug therapy*
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Staphylococcal Infections / microbiology
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Teicoplanin / pharmacology*
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Vancomycin Resistance*
Substances
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Glycopeptides
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Teicoplanin
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dalbavancin