Abstract
To elucidate the control of hepatic cholesterol metabolism by leptin, rats were administered IV (intravenous) leptin, ICV (intracerebroventricular) leptin or saline. A single low dose of ICV leptin was as effective as a continuous IV infusion of high-dose leptin at decreasing the activities of 3-hydroxy-3-methylglutaryl-CoA reductase and cholesterol 7alpha-hydroxylase. These results indicate that the hepatic response to leptin is transduced via the central nervous system.
Publication types
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Comparative Study
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Cerebral Ventricles
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Cholesterol / blood
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Cholesterol / metabolism*
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Cholesterol 7-alpha-Hydroxylase / metabolism
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Hydroxymethylglutaryl CoA Reductases / metabolism
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Infusions, Intravenous
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Infusions, Parenteral
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Leptin / administration & dosage
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Leptin / pharmacology*
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Lipids / blood
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Lipoproteins / blood
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Liver / drug effects
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Liver / metabolism*
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Male
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Rats
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Rats, Sprague-Dawley
Substances
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Leptin
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Lipids
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Lipoproteins
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lipoprotein cholesterol
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Cholesterol
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Hydroxymethylglutaryl CoA Reductases
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Cholesterol 7-alpha-Hydroxylase