Abstract
While most BK virus infections are asymptomatic, immunosuppression has been associated with BK virus reactivation and impaired graft function or ureteric ulceration in renal transplant patients and hemorrhagic cystitis in bone marrow transplant patients. Oncogenicity is also postulated and this is the first report of a child with a carcinoma of the donor renal pelvis following BK virus allograft nephropathy. Removal of the primary tumor and cessation of immunosuppression led to regression of secondary tumors and a return to health.
MeSH terms
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Adenocarcinoma / immunology*
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Adenocarcinoma / pathology
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Adenocarcinoma / virology
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BK Virus
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Child
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Genetic Diseases, X-Linked / complications
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Humans
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Immunocompromised Host*
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Immunosuppressive Agents / therapeutic use
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Kidney Diseases / pathology
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Kidney Diseases / virology
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Kidney Neoplasms / immunology*
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Kidney Neoplasms / pathology
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Kidney Neoplasms / virology
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Kidney Transplantation*
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Male
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Polyomavirus Infections / immunology*
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Polyomavirus Infections / pathology
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Renal Insufficiency / etiology
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Renal Insufficiency / surgery
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Tacrolimus / therapeutic use
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Tumor Virus Infections / immunology*
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Tumor Virus Infections / pathology
Substances
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Immunosuppressive Agents
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Tacrolimus