Abstract
A 42-year-old man with human immunodeficiency virus (HIV) infection and a history of complex partial seizures developed severe anemia after the addition of valproic acid to his stable antiretroviral regimen of zidovudine, lamivudine, and abacavir. The inhibition of zidovudine glucuronidation by valproic acid and the resultant zidovudine hematologic toxicity is the proposed mechanism of the interaction.
MeSH terms
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Anemia / chemically induced*
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Anti-HIV Agents / therapeutic use
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Antiretroviral Therapy, Highly Active
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Dideoxynucleosides / therapeutic use
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Drug Interactions
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Epilepsy, Complex Partial / complications
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HIV Infections / complications
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HIV Infections / drug therapy
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Humans
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Lamivudine / therapeutic use
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Male
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Valproic Acid / adverse effects*
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Valproic Acid / therapeutic use
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Zidovudine / adverse effects*
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Zidovudine / therapeutic use
Substances
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Anti-HIV Agents
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Dideoxynucleosides
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Lamivudine
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Zidovudine
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Valproic Acid
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abacavir