Abstract
Host-guest association between four CENS (derivated from piperidine, dibenzylamine, dicyclohexylamine and methyl prolinate) and beta-cyclodextrin was carried out in solution and solid state. Characterisation, stoichiometry, solubility, dissociation constants and stability of such complexes were studied, showing that the inclusion with beta-CD appears as a promising mode of formulation of 2-chloroethylnitrososulfamides.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amides / chemical synthesis
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Amides / chemistry*
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Antineoplastic Agents / chemistry
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Cyclodextrins / chemistry*
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Drug Carriers / chemistry
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Drug Stability
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Macromolecular Substances
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Magnetic Resonance Spectroscopy / methods
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Models, Molecular
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Molecular Structure
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Nitrogen Isotopes
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Nitroso Compounds / chemical synthesis
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Nitroso Compounds / chemistry*
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Octanols / chemistry
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Sulfones / chemical synthesis
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Sulfones / chemistry*
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Water / chemistry
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beta-Cyclodextrins*
Substances
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Amides
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Antineoplastic Agents
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Cyclodextrins
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Drug Carriers
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Macromolecular Substances
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Nitrogen Isotopes
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Nitroso Compounds
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Octanols
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Sulfones
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beta-Cyclodextrins
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Water
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betadex