Analysis of the type 2 diabetes-associated single nucleotide polymorphisms in the genes IRS1, KCNJ11, and PPARG2 in type 1 diabetes

Diabetes. 2004 Mar;53(3):870-3. doi: 10.2337/diabetes.53.3.870.

Abstract

It has been proposed that type 1 and 2 diabetes might share common pathophysiological pathways and, to some extent, genetic background. However, to date there has been no convincing data to establish a molecular genetic link between them. We have genotyped three single nucleotide polymorphisms associated with type 2 diabetes in a large type 1 diabetic family collection of European descent: Gly972Arg in the insulin receptor substrate 1 (IRS1) gene, Glu23Lys in the potassium inwardly-rectifying channel gene (KCNJ11), and Pro12Ala in the peroxisome proliferative-activated receptor gamma2 gene (PPARG2). We were unable to confirm a recently published association of the IRS1 Gly972Arg variant with type 1 diabetes. Moreover, KCNJ11 Glu23Lys showed no association with type 1 diabetes (P > 0.05). However, the PPARG2 Pro12Ala variant showed evidence of association (RR 1.15, 95% CI 1.04-1.28, P = 0.008). Additional studies need to be conducted to confirm this result.

Publication types

  • Multicenter Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Amino Acid Substitution
  • Canada
  • Child
  • Diabetes Mellitus, Type 1 / genetics*
  • Diabetes Mellitus, Type 2 / genetics
  • Europe
  • Female
  • Humans
  • Insulin Receptor Substrate Proteins
  • Male
  • Phosphoproteins / genetics*
  • Polymorphism, Single Nucleotide / genetics*
  • Potassium Channels, Inwardly Rectifying / genetics*
  • Receptors, Cytoplasmic and Nuclear / genetics*
  • Transcription Factors / genetics*

Substances

  • IRS1 protein, human
  • Insulin Receptor Substrate Proteins
  • Kir6.2 channel
  • Phosphoproteins
  • Potassium Channels, Inwardly Rectifying
  • Receptors, Cytoplasmic and Nuclear
  • Transcription Factors