Abstract
1. delta-Aminolevulinic acid synthetase (ALA-S), rhodanese and microsomal heme oxygenase (MHO), were quantitated in Cl4C induced regenerating mouse liver. 2. Maximal hepatomegalia was observed at 48 hr after i.p. injection of a single dose of the toxin. 3. ALA-S activity decreased on day 2, and then significantly increased (50%) between days 3 and 7, returning afterwards to control values. 4. Cytoplasmic rhodanese, as well as MHO activities, exhibited a clear correlation as compared with the ALA-S activity profile. 5. Porphyrin biosynthesis from precursor delta-aminolevulinic acid (ALA) was significantly increased even after 15 days of intoxication. 6. Present results would indicate that Cl4C is acting in a dual fashion.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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5-Aminolevulinate Synthetase / metabolism
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Aminolevulinic Acid / metabolism
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Animals
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Carbon Tetrachloride / pharmacology
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Cytochrome P-450 Enzyme System / deficiency
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Heme / metabolism*
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Heme Oxygenase (Decyclizing) / metabolism
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Kinetics
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Liver / drug effects
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Liver / enzymology
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Liver / metabolism*
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Liver Regeneration / drug effects
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Liver Regeneration / physiology*
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Mice
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Microsomes, Liver / drug effects
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Microsomes, Liver / enzymology
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Porphyrins / biosynthesis
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Thiosulfate Sulfurtransferase / metabolism
Substances
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Porphyrins
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Heme
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Aminolevulinic Acid
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Cytochrome P-450 Enzyme System
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Carbon Tetrachloride
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Heme Oxygenase (Decyclizing)
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5-Aminolevulinate Synthetase
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Thiosulfate Sulfurtransferase