Abstract
The chronic hepatotoxic effects of carbon tetrachloride (CCl(4)) in heat-shock protein (HSP) 70 knock out (HSP70-/-) mice were examined. After repeated intraperitoneal injections of CCl(4) for six weeks, the level of ALT and weight ratio of the liver to body were lower in HSP70-/- mice than in the control (WT) mice. The levels of HSP25 and HSP47 were lowered in HSP70-/- mice as compared with WT mice. The grades of hepatic necrosis and neutrophil infiltration were not significantly different between HSP70-/- and WT mice. The collagen content was not affected significantly by CCl(4) treatment.
Publication types
-
Comparative Study
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Alanine Transaminase / blood*
-
Animals
-
Blotting, Western
-
Body Weights and Measures
-
Carbon Tetrachloride / toxicity*
-
Electrophoresis, Polyacrylamide Gel
-
HSP47 Heat-Shock Proteins
-
HSP70 Heat-Shock Proteins / genetics*
-
Heat-Shock Proteins / metabolism
-
Liver / drug effects*
-
Liver / metabolism
-
Liver / pathology
-
Mice
-
Mice, Knockout
-
Molecular Chaperones
-
Neoplasm Proteins / metabolism
-
Neutrophil Infiltration
-
Neutrophils / pathology
Substances
-
HSP47 Heat-Shock Proteins
-
HSP70 Heat-Shock Proteins
-
Heat-Shock Proteins
-
Hsbp1 protein, mouse
-
Molecular Chaperones
-
Neoplasm Proteins
-
Serpinh1 protein, mouse
-
Carbon Tetrachloride
-
Alanine Transaminase