Non-pigmenting fixed drug eruption caused by allylisopropylacetylurea

Contact Dermatitis. 2003 Oct;49(4):175-9. doi: 10.1111/j.0105-1873.2003.0212.x.

Abstract

An unusual case of a non-pigmenting fixed drug eruption caused by allylisopropylacetylurea is reported. Several hours after taking an analgesic (New Kaiteki A), a 30-year-old Japanese woman, who had experienced similar eruptions several times after taking other analgesics, developed numerous variously sized, itchy, round-to-oval erythematous eruptions on the trunk and extremities. After she discontinued taking this drug, all such eruptions resolved within 2 weeks, without leaving postinflammatory pigmentation. Patch testing with New Kaiteki A itself and one of its active ingredients, allylisopropylacetylurea, on lesional skin, but not on uninvolved skin, showed positive erythematous reactions after 2 days.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Drug Eruptions / etiology*
  • Female
  • Humans
  • Hypnotics and Sedatives / adverse effects*
  • Hypnotics and Sedatives / chemistry
  • Molecular Structure
  • Patch Tests
  • Urea / adverse effects*
  • Urea / analogs & derivatives*
  • Urea / chemistry

Substances

  • Hypnotics and Sedatives
  • Urea
  • apronalide