Abstract
Ovarian ablation is an effective treatment for premenopausal women with hormone receptor positive breast cancer. It can be achieved permanently by surgery or radiotherapy and reversibly by LhRH agonists. This paper discusses the evidence that it is an effective adjuvant therapy and defines the place of oophorectomy in the management of such patients. The achievement of an amenhorreic state is important and chemotherapy may well exert some of its effects by causing ovarian suppression. The use of LhRH agonists in managing such patients is discussed.
MeSH terms
-
Adult
-
Antineoplastic Agents, Hormonal / therapeutic use
-
Antineoplastic Combined Chemotherapy Protocols / therapeutic use
-
Breast Neoplasms / mortality
-
Breast Neoplasms / pathology
-
Breast Neoplasms / therapy*
-
Combined Modality Therapy
-
Estrogen Receptor Modulators / therapeutic use*
-
Female
-
Follow-Up Studies
-
Gonadotropin-Releasing Hormone / therapeutic use*
-
Humans
-
Middle Aged
-
Neoplasm Staging
-
Ovariectomy / methods*
-
Premenopause
-
Randomized Controlled Trials as Topic
-
Receptors, Estrogen / drug effects*
-
Risk Assessment
-
Sensitivity and Specificity
-
Survival Analysis
-
Tamoxifen / adverse effects
-
Tamoxifen / therapeutic use
-
Treatment Outcome
Substances
-
Antineoplastic Agents, Hormonal
-
Estrogen Receptor Modulators
-
Receptors, Estrogen
-
Tamoxifen
-
Gonadotropin-Releasing Hormone