The serotonin transporter gene in aggressive children with and without ADHD and nonaggressive matched controls

Joseph H Beitchman; Kristen M Davidge; James L Kennedy; Leslie Atkinson; Vivien Lee; Solomon Shapiro; Lori Douglas

doi:10.1196/annals.1301.025

The serotonin transporter gene in aggressive children with and without ADHD and nonaggressive matched controls

Ann N Y Acad Sci. 2003 Dec:1008:248-51. doi: 10.1196/annals.1301.025.

Authors

Joseph H Beitchman¹, Kristen M Davidge, James L Kennedy, Leslie Atkinson, Vivien Lee, Solomon Shapiro, Lori Douglas

Affiliation

¹ Department of Psychiatry, Hospital for Sick Children, Toronto, Ontario, Canada.

PMID: 14998889
DOI: 10.1196/annals.1301.025

Abstract

Using an ethnically homogeneous sample of highly aggressive Caucasian children and their matched controls, we report differential associations of the 5HTTLPR and VNTR polymorphisms with ADHD and aggression, respectively. Given the small sample size and the preliminary nature of our findings, replication is necessary.

MeSH terms

Aggression / psychology*
Attention Deficit Disorder with Hyperactivity / genetics*
Attention Deficit Disorder with Hyperactivity / psychology*
Carrier Proteins / genetics*
Case-Control Studies
Child
Genotype
Humans
Membrane Glycoproteins / genetics*
Membrane Transport Proteins*
Nerve Tissue Proteins*
Polymorphism, Genetic / genetics
Serotonin / genetics*
Serotonin Plasma Membrane Transport Proteins

Substances

Carrier Proteins
Membrane Glycoproteins
Membrane Transport Proteins
Nerve Tissue Proteins
SLC6A4 protein, human
Serotonin Plasma Membrane Transport Proteins
Serotonin