Abstract
A monoclonal antibody recognizing ets proteins from a variety of species has been developed. This antibody recognizes ets1, ets2, erg, and other related proteins. It has a high affinity for the ets1 protein. The epitope for the pan ets mAb consists of about 13 amino acids. This antibody can be used to isolate and characterize new members of ets gene family derived from a c-DNA expression library, as well as to identify other "ets motif" binding proteins.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Amino Acid Sequence
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Animals
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Antibodies, Monoclonal*
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Antigens / genetics
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Antigens / immunology
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Base Sequence
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Binding Sites
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DNA / genetics
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DNA-Binding Proteins / genetics
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DNA-Binding Proteins / immunology
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Humans
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Hybridomas / immunology
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Molecular Sequence Data
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Multigene Family
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Peptides / genetics
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Peptides / immunology
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Retroviridae Proteins, Oncogenic / genetics*
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Retroviridae Proteins, Oncogenic / immunology*
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Species Specificity
Substances
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Antibodies, Monoclonal
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Antigens
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DNA-Binding Proteins
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Peptides
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Retroviridae Proteins, Oncogenic
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oncogene proteins v-ets
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DNA