Sero-epidemiology of Bordetella pertussis in England and Wales

Vaccine. 2004 Mar 12;22(9-10):1314-9. doi: 10.1016/j.vaccine.2003.08.039.

Abstract

The incidence of pertussis infection can be estimated in the population by defining a single high titre of anti pertussis toxin (PT) immunoglobulin G (IgG) antibody predictive of recent infection. Sera samples collected in 1986, 1996 or annually between 1987 and 1998 were tested for anti-PT IgG antibody. In 1996, the age-adjusted prevalence of pertussis infection was 1.2% and was higher in children than in adults. Amongst samples collected annually, older age and female sex, but none of the temporal variables, were associated with a serologically defined pertussis infection. There is an important incidence of infection in the population, which is greater amongst children than adults, but there is only limited evidence of a correlation with epidemic cycles.

MeSH terms

  • Age Factors
  • Bordetella pertussis / immunology*
  • Child
  • Child, Preschool
  • England / epidemiology
  • Female
  • Humans
  • Immunoglobulin G / analysis
  • Immunoglobulin G / biosynthesis
  • Male
  • Mass Vaccination
  • Monitoring, Immunologic
  • Pertussis Toxin / immunology
  • Pertussis Vaccine
  • Wales / epidemiology
  • Whooping Cough / epidemiology*
  • Whooping Cough / immunology*

Substances

  • Immunoglobulin G
  • Pertussis Vaccine
  • Pertussis Toxin