4. The natural products epothilones A and B as lead structures for anticancer drug discovery: chemistry, biology, and SAR studies

Prog Med Chem. 2004:42:171-205. doi: 10.1016/S0079-6468(04)42004-9.
No abstract available

Publication types

  • Review

MeSH terms

  • Animals
  • Antineoplastic Agents / chemical synthesis
  • Antineoplastic Agents / metabolism
  • Antineoplastic Agents / pharmacology*
  • Epothilones / chemical synthesis
  • Epothilones / metabolism
  • Epothilones / pharmacology*
  • Humans
  • Microtubules / drug effects
  • Microtubules / metabolism
  • Neoplasms / drug therapy
  • Neoplasms / metabolism
  • Structure-Activity Relationship
  • Tubulin / metabolism

Substances

  • Antineoplastic Agents
  • Epothilones
  • Tubulin
  • epothilone A
  • desoxyepothilone B
  • epothilone B