First molecular identification of human Dobrava virus infection in central Europe

Boris Klempa; Morten Schütt; Brita Auste; Milan Labuda; Rainer Ulrich; Helga Meisel; Detlev H Krüger

doi:10.1128/JCM.42.3.1322-1325.2004

First molecular identification of human Dobrava virus infection in central Europe

J Clin Microbiol. 2004 Mar;42(3):1322-5. doi: 10.1128/JCM.42.3.1322-1325.2004.

Authors

Boris Klempa¹, Morten Schütt, Brita Auste, Milan Labuda, Rainer Ulrich, Helga Meisel, Detlev H Krüger

Affiliation

¹ Institute of Virology, University Hospital Charité, D-10098 Berlin, Germany.

Abstract

Viral RNA was amplified by reverse transcription-PCR from a patient suffering from hemorrhagic fever with renal syndrome (HFRS) in Germany. The virus strain could be assigned to the Dobrava hantavirus (DOBV). This is the first molecular identification of human infection by DOBV in central Europe and the first proof that a virus strain related to the DOBV-Aa lineage, carried by Apodemus agrarius rodents, is able to cause HFRS.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Animals
Germany
Hantavirus Infections / diagnosis*
Hantavirus Infections / transmission
Hemorrhagic Disorders / complications
Hemorrhagic Disorders / virology
Humans
Kidney Diseases / complications
Kidney Diseases / virology
Male
Molecular Sequence Data
Muridae / virology
Orthohantavirus / classification
Orthohantavirus / genetics
Orthohantavirus / isolation & purification*
Phylogeny
RNA, Viral / genetics
RNA, Viral / isolation & purification
Reverse Transcriptase Polymerase Chain Reaction / methods

Substances

RNA, Viral

Associated data

GENBANK/AY533117
GENBANK/AY533118
GENBANK/AY533119
GENBANK/AY533120
GENBANK/AY533121