Abstract
Clostridium perfringens causes necrotic enteritis in chickens, and alpha-toxin has been suggested to be a key virulence determinant. Analysis of the alpha-toxin of 25 chicken-derived C. perfringens strains demonstrated high homology to mammal-derived strains rather than to the only avian-derived C. perfringens alpha-toxin sequence reported previously.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Animals
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Australia
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Bacterial Toxins / chemistry
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Bacterial Toxins / genetics*
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Base Sequence
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Calcium-Binding Proteins*
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Chickens
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Clostridium Infections / diagnosis
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Clostridium Infections / veterinary*
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Clostridium perfringens / isolation & purification*
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Conserved Sequence
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DNA Primers
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Humans
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Intestinal Mucosa / microbiology
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Molecular Sequence Data
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Polymerase Chain Reaction
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Poultry Diseases / diagnosis
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Poultry Diseases / microbiology*
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Sequence Alignment
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Sequence Homology, Amino Acid
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Type C Phospholipases / chemistry
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Type C Phospholipases / genetics*
Substances
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Bacterial Toxins
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Calcium-Binding Proteins
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DNA Primers
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Type C Phospholipases
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alpha toxin, Clostridium perfringens