Abstract
We report the first longitudinal analysis of cerebrospinal fluid (CSF) F2-isoprostanes (IsoPs), quantitative in vivo biomarkers of lipid peroxidation, in patients with mild Alzheimer's disease (AD). CSF F2-IsoPs (i) were significantly increased in patients followed over one year, (ii) correlated with some clinical indices of dementia following correction for variation in ventricular enlargement, and (iii) were significantly lower in patients who used both alpha-tocopherol and vitamin C.
Publication types
-
Research Support, Non-U.S. Gov't
-
Research Support, U.S. Gov't, Non-P.H.S.
-
Research Support, U.S. Gov't, P.H.S.
MeSH terms
-
Aged
-
Alzheimer Disease / cerebrospinal fluid*
-
Alzheimer Disease / diagnosis
-
Alzheimer Disease / drug therapy
-
Antioxidants / administration & dosage
-
Ascorbic Acid / administration & dosage
-
Biomarkers / cerebrospinal fluid
-
Cerebral Ventricles / pathology
-
Disease Progression
-
F2-Isoprostanes / cerebrospinal fluid*
-
Female
-
Humans
-
Lipid Peroxidation / drug effects
-
Lipid Peroxidation / physiology
-
Longitudinal Studies
-
Male
-
Mental Status Schedule
-
Middle Aged
-
Statistics as Topic
-
alpha-Tocopherol / administration & dosage
-
tau Proteins / cerebrospinal fluid
Substances
-
Antioxidants
-
Biomarkers
-
F2-Isoprostanes
-
tau Proteins
-
alpha-Tocopherol
-
Ascorbic Acid