Abstract
Solid-phase synthetic methods for biaryl-based compounds were developed resulting in the construction of two 1000-member libraries. Numerous compounds were identified by high-throughput screening using whole cell screens to exhibit anti-microbial activity against Gram-positive bacteria. A series of biaryl compounds containing natural and unnatural amino acids were made to explore the SAR of the amino acid functionality.
MeSH terms
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Amides / chemistry
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Amides / pharmacology*
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Amino Acids / chemistry
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Amino Acids / pharmacology*
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / pharmacology*
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Escherichia coli / drug effects*
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Escherichia coli / growth & development
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Gram-Positive Bacteria / drug effects
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Gram-Positive Bacteria / growth & development
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Microbial Sensitivity Tests / statistics & numerical data
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Staphylococcus aureus / drug effects*
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Staphylococcus aureus / growth & development
Substances
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Amides
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Amino Acids
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Anti-Bacterial Agents