Abstract
A library of pentapeptides containing the sequence -Y-X-Y- based on rational design was screened with six different lectins. Sequences were identified that modulate galectin binding to its natural carbohydrate ligand. SPR showed inhibition values 2-3 times stronger than galactose and NMR studies suggested real carbohydrate mimicry.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Dose-Response Relationship, Drug
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Galactose / chemistry
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Galactose / metabolism*
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Lectins / chemistry
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Lectins / metabolism*
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Ligands
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Molecular Sequence Data
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Oligopeptides / chemistry
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Oligopeptides / metabolism*
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Protein Binding / physiology
Substances
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Lectins
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Ligands
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Oligopeptides
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Galactose