Background: The objective of this study was to establish the relationship between presence of anti-Chlamydia trachomatis and anti-HSP60 antibodies in serum and follicular fluid of infertile women.
Methods: Serum IgG and follicular fluid IgA to Chlamydia trachomatis and human heat shock protein 60 (HSP60) were determined in 41 women undergoing in vitro fertilization (IVF).
Results: A significant association was found between presence of bacterial antibodies in serum and IgA anti-HSP60 in follicular fluid.
Conclusions: Chlamydia trachomatis infection might be triggering an autoimmune process that could negatively affect the success of IVF.