Abstract
Ca(2+) is a major trigger for pulmonary vasoconstriction and a stimulus for pulmonary vascular smooth muscle cell proliferation. The transient receptor potential cation channels participate in regulating intracellular Ca(2+) and thus vascular contractility and cell proliferation. Upregulation of genes encoding these channels is involved in the development of pulmonary hypertension.
Publication types
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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Calcium Channels / physiology*
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Cell Division / physiology
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Humans
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Hypertension, Pulmonary / pathology
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Hypertension, Pulmonary / physiopathology*
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Muscle, Smooth, Vascular / cytology
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Muscle, Smooth, Vascular / physiology*
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Pulmonary Artery / cytology*
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TRPC Cation Channels
Substances
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Calcium Channels
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TRPC Cation Channels